MS4A1（CD20）

Q1: What is MS4A1 and what does it encode?

MS4A1 encodes CD20, a B-cell surface transmembrane protein belonging to the membrane-spanning 4A family.

Q2: What is the biological function of MS4A1?

MS4A1 regulates calcium influx in B cells and plays a critical role in B-cell activation, differentiation, and proliferation.

Q3: Where is MS4A1 expressed?

It is primarily expressed on the surface of B lymphocytes from early developmental stages until differentiation into plasma cells.

Q4: Why is MS4A1 important in disease research?

MS4A1 is a key therapeutic target in B-cell malignancies such as lymphoma and leukemia, and is widely used in antibody-based therapies.